10º Foro de Inmunologia Traslacional en Inmmunoterapia del cáncer

17 10º FORO DE Inmunología Traslacional e INMUNOTERAPIA DEL CÁNCER CP-12. COMBINATION OF MRNA-ENCODED BISPECIFIC ANTIBODIES FOR IMPROVED AND SAFER CANCER IMMUNOTHERAPY Oana Hangiu1,2,3; Rocío Navarro1; Susana Frago1; Laura Rubio-Pérez2,3,4,5; Laura Díez2,3; Marina Gómez-Rosel1,2,3,4; Marta Compte1; Luis Álvarez-Vallina2,3,4,5 1Department of Antibody Engineering, Leadartis SL, QUBE Technology Park, 28760 Tres Cantos, Madrid, Spain; 2Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario12 de Octubre (H12O), 28041 Madrid, Spain; 3Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, Spain; 4H12O-CNIO Cancer Immunotherapy Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain; 5Chair for Immunology UFV/Merck, Universidad Francisco de Vitoria (UFV), 28223 Pozuelo de Alarcón, Madrid, Spain CP-13. METABOLIC PRIMING OF LUNG METASTATIC NICHE DRIVES PALMITATE AVAILABILITY AND NF- κB SIGNALING IN BREAST CANCER Patricia Altea-Manzano1,2,3; Yawen Li2,3; Ginevra Doglioni2,3; Emma Nolan4; Juan FernándezGarcía2,3; Ilaria Malanchi4; Sarah-Maria Fendt2,3 1Laboratory of Metabolic regulation and Signaling in Cancer, CABIMER-CSIC, Sevilla, Spain. 2Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium. 3Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium. 4The Francis Crick Institute, London, United Kingdom CP-14. PT-112 INDUCES POTENT MITOCHONDRIAL STRESS AND IMMUNOGENIC CELL DEATH IN HUMAN PROSTATE CANCER CELL LINES Ruth Soler Agesta1; Raquel Moreno Loshuertos1; Christina Y. Yim2; Maria T. Congenie2; Tyler D. Ames2; Hannah L. Johnson3; Fabio Stossi3; Joaquín Marco Brualla1; M. ª Concepción Junquera4; Raquel Martínez de Mena5; José Antonio Enríquez5; Lorenzo Galluzzi6; Matthew R. Price2; José Jimeno1,2; Alberto Anel1 1Universidad de Zaragoza/Instituto Aragonés de Ciencias de la Salud (IIS-Aragón), Biochemistry and Molecular and Cell Biology, Zaragoza, Spain. 2Promontory Therapeutics Inc., New York, USA. 3Baylor College of Medicine, Integrated Microscopy Core, Houston, Texas, USA. 4Department of Anatomy and Human Histology, Faculty of Medicine, Universidad de Zaragoza/Instituto Aragonés de Ciencias de la Salud (IIS-Aragón), Zaragoza, Spain. 5Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; 6Weill Cornell Medicine, New York, USA CP-15. TUMOR PROGRESSION MODIFIES THE EXPRESSION OF VASCULAR LAMININS AND THE IMMUNE LANDSCAPE IN THE SENTINEL LYMPH NODE Elena Nonnast Fornieles1; Rosa María Peregil1; Miguel Ángel Sánchez1; María del Carmen MorenoOrtiz1; Elena Hernández2; Salvador Iborra2; Santos Mañes Brotón1; Emilia Mira Damaso1 1Centro Nacional de Biotecnología - CNB-CSIC, Madrid, Spain. 2Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain

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